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There have been postmarketing reports of venous thromboembolic events, including deep vein thrombosis (DVT) and pulmonary embolism (PE), in patients using testosterone products, such as testosterone cypionate

As LTB4 is synthesized by 5-lipoxygenase, attempts have been made to inhibit this enzyme (e.g., GSK2190915, Zileuton) but have also failed because of side effects including hepatic toxicity [110]

Genetics of caffeine consumption and responses to caffeine