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Therefore, the effects of these two systems on HIFs and NRF2 signaling systems are complex, implying the presence of a network connecting these two systems

Nrf2 expression is upregulated in tumor infiltrating T cells and induces T cell anergy

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Zhang W, Rohlmann A, Sargsyan V, Aramuni G, Hammer RE, Sdhof TC, et al

In addition to its role in oxidizing macromolecules such as proteins and lipids, H 2 O 2 has also been proposed to function as a signal to induce the expression of genes involved in the senescence process ( Arabidopsis could be induced by ozone (Miller et al., 1999) and the expression of many other SAGs were also induced by ROS ( 2 O 2 treatment in both leaves and roots ( Distinct from the positive role of ROS in senescence, NO can both provoke and impede this process, dependent upon its concentration and subcellular location