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Septic cardiomyopathy (SIC) In a model of LPS-mediated septic cardiomyopathy, some researchers revealed that LPS caused ferroptosis and septic cardiac injury by downregulating GPX4 protein levels and increasing COX-2 [93]
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One way this is done is through conjugation with GST (glutathione S-transferase) enzymes
In conclusion, FSP1, CoQ10, and NADPH comprise an anti-ferroptosis system parallel to GSH
