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Regarding your second question around whether the temperature distribution in the refrigerator can be affected by stacking vaccines, and therefore affect vaccine potency, this is a somewhat tricky issue

Targeting NAM binding site As an endogenous product of the NNMT-catalyzed reaction, 1-MNA (IC 50 = 9.0 0.6 M) is a prototype NNMT inhibitor that engages the NAM binding site, which has been traditionally used in pharmacological evaluations of NNMT functions

Then you may recall that the product of metabolism is ATP, which the bodys cells use as energy

Research confirms this consistently
