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Here we show that LMP1 inhibits the integrated stress response (ISR) pathway in normal oral keratinocytes by attenuating phosphorylation of the eIF2 translation initiation factor by the PERK and GCN2 kinases

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These pathways allow the body to process and eliminate toxins efficiently

The literature search supports the conclusion that metformin is neuroprotective against DM-induced neuronal cell degeneration in both peripheral and central nervous systems, and this effect is likely mediated via modulation of oxidative stress, inflammation, and cell death pathways.

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