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He noted that MTHFD2 is a bifunctional enzyme with both MTHFD and cyclohydrolase activities that distinguish it from the homologous trifunctional cytoplasmic enzyme MTHFD1 that includes dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase activities

Research suggests that HSCs typically constitute 5%8% of a healthy human liver, primarily regulating ECM synthesis and degradation to modulate hepatic sinusoidal blood supply (El-Serag, 2012)

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