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The combined-formulation Phase 3 REDEFINE-1 data (PMID 40544433) extended the tolerability characterisation into the larger and longer-duration cohort

[DOI] [PubMed] [Google Scholar] 20.Storck T., Schulte S., Hofmann K., Stoffel W

Finally, the different mechanisms of action for 5-FU and oxaliplatin may explain why 5-FU, but not oxaliplatin, increases H2AX caused by the inactivation of GSTA4

doi: 10.1038/sj.sc.3101116, 41 TakedaK.MuramatsuM.ChikumaT.KatoT

FIGURE 5 For the Intermediate treatment, in the category of biological process, small molecule metabolic process, metabolic process, alcohol metabolic process, hexose metabolic process, and small molecule catabolic process were significantly enriched (Figure 5)
