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The mechanism of medicinal plants is broad, and includes regulation of intestinal microbiota composition and intestinal permeability, increased expression of both mRNA and claudin-1 protein, and anti-inflammatory effects (Chinese tea, hibiscus, liquorice, marshmallow, ginger root, peppermint, plantain, curcumin)

Increased side effects can include bone marrow damage

The culprit

According to ICH guidelines accelerated stability test for a product intended for storage in refrigerator needs a study at 25C

The elevated homocysteine creates further oxidative stress and neuroinflammation, which in turn damages the myelin sheath and worsens the cognitive dysfunction and neuropathy