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In LPS- or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated PD animals, the IKK activity is increased in substantia nigra because of the overexpression of its phosphorylation [70-72], which significantly promoted LPS-induced neurotoxicity [71], such as dopaminergic and tyrosine hydroxylase positive cell death, while its genetic abolishment or inhibition of IKK attenuated the neuroinflammation [70, 73-76]

[DOI] [PMC free article] [PubMed] [Google Scholar] 329.Akhter, F., Chen, D., Akhter, A., Yan, S

Synthetic antioxidants are categorized into many groups based on how they function

For instance, targeting glutamine synthetase (GS), the enzyme that catalyzes the conversion of glutamate to glutamine, represents an alternative strategy to perturb glutamine homeostasis within cancer cells [67]

It will also boost immunity and aid in cellular repair