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The knowledge gained about the classical and non-classical pathways of ferroptosis elucidates potential targets for interventions aimed at ameliorating COPD pathology ( Figure 4 )

Skin microbiome and its ecological niches Mammalian skin, the bodys largest organ, prevents water loss, regulates temperature, and protects against physical, chemical and microbial insults

Figure 3 Most of these antioxidant enzymes not only eliminate the free radicals produced by viral infection, but also contribute to decrease cytokine-mediated inflammation through the induction of leukotriene B4 reductase, a NAD(P)H-dependent oxidoreductase which inactivates leukotriene B4 involved in the inflammation and reduces oxidative stress counteracting the iron overload by increasing the ferritin levels (Dick et al., 2001)

Although it is a unique drug, prolonged treatment with therapeutic levels may cause multisystem toxicity [25]

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