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As for the results of this trial, the MSCs were deemed to be safe, well tolerated, and feasible

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In 2014, Smith and colleagues studied two unrelated families with SSMD using whole exome sequencing and identified bi-allelic truncating variants in the GPX4 gene, which encodes glutathione peroxidase 4 (GPX4), thus proposing a molecular basis for SSMD [13]

For the temperature stresses, compared with the optimum growth temperature 29, at 25, 35 and 37, the growth of CK and recombinant yeast was approximately the same, while at 40, yeast in all the groups unable grow normally, which were inhibited by high temperature