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Cu 2 O can effectively release Cu + within the TME, facilitating CDT, and concurrently generate O 2 to mitigate hypoxia

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With the shift towards glycolysis, there is a reduction in oxidative phosphorylation affecting the mitochondria and its function

The carefully designed vaccine platform not only achieves precise spatiotemporal targeted delivery of the vaccine, but also has the function of modulating the immunosuppressive TME, thereby inducing a strong tumor antigen-specific response (Zhang et al., 2021)

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