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The main medication currently available is levodopa in combination with dopamine antagonists and monoamine oxidase-B (MAO-B) inhibitors, to prolong the benefits of levodopa [34]

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It encourages angiogenesis, cuts down on inflammation, supports nerve healing, and boosts collagen production

Physical exercise stimulates tissue rejuvenation and repair as well as resets the circadian rhythms altered by aging and age-mediated diseases especially cardiovascular, neurodegeneration, cancer, obesity and liver dysfunction that are primarily due to impairments in metabolic homeostasis (Silva et al., 2021