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However, interpretation of these signatures may be confounded by kidney function and medication use, and clinical translation will require rigorous external validation, particularly in prospective cohorts and trials specifically designed for DKD

Biofilms not only shield micro-organisms from changes in pH, osmolarity, lack of nutrition, mechanical stress, and shear forces but also prevent bacterial biofilm communities from being accessed by antibiotics and the immune cells of the host [40,43,44,45]

Drug Delivery and Translational Research, 12 , 931943

( Moderate Recommendation, Evidence Level: Grade C) Recurrent Ischemic Priapism Clinicians should inform patients with recurrent ischemic priapism that optimal strategies to prevent subsequent episodes are unknown