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High levels of this compound were also associated with worse kidney function and advanced chronic kidney disease in 227 patients with heart disease [22]

Introduction Obesity is featured as massive fat accumulation that not only causes weight gain but also induces chronic low-grade inflammation, which further triggers vascular dysfunction and metabolic abnormalities and ultimately results in cardiovascular diseases and type 2 diabetes (T2D) [1,2]

The authors suggest that inhibition of FAO may lead to an overall decrease in cancer cell survival, while an increase in CPT1 activity, such as the PRL-mediated response, may provide a supportive environment for malignant cells 36

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Samples taken in 2019 (49 RA, 23 OA, 25 healthy individuals) were selected for the discovery cohort, and those taken in 2020 (62 RA and 22 OA) were selected as the internal validation cohort