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These cells are also specialized to recognize bacterial-derived molecules, known as prokaryotic-associated molecular patterns, with the help of the Toll-like receptors on the cell surface and the nucleotide-binding oligomerization domain-like receptors in the cytoplasm, which activate defense mechanisms by the secretion of anti-microbial peptides 2

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Long noncoding ZC3H7A (LncZC3H7A), which has been suggested to be transcriptionally co-regulated with ZC3H7A expression, facilitated elevated levels of type I IFN in response to viral infections

4.3 Mitochondrial redox signaling as a bidirectional regulator of sleep and cellular homeostasis Mitochondria are the primary source of intracellular ROS, generating approximately 90% of cellular ROS as byproducts of oxidative phosphorylation (Sena and Chandel, 2012