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The mechanistic data strongly suggests it could
doi: 10.1038/nrd747
Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals
Examples of this include human growth hormone (Llompart et al., 2010) and enhanced cyan fluorescent protein (Torrent et al., 2009)
doi: 10.1253/circj.70.1231
