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The most frequently mutated genesCDKN2A, TP53, KRAS, and SMAD4currently lack viable pharmacological targets, significantly hindering the development of effective treatment options [6]

One study demonstrated increased distal leg IENFD by 1.5 fibres mm 1 in patients with diabetes (without neuropathy) who received a weekly structured and supervised exercise programme, but IENFD was unchanged in patients who received lifestyle counselling (0.1 fibres mm 1

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It plays an integral role in a number of bodily functions, including DNA production and the formation and maintenance of red blood cells and nerve cells

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