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Next, Nrf2 is degraded rapidly by proteasome keeping low basal levels of Nrf2 (Zimta et al., 2019)

In the next sections, we will briefly introduce thiazides, thiazide-like and loop diuretics from a historic perspective to illustrate how the success of one specific class of these diuretics in treating hypertension overshadowed their undesired metabolic effects and reduced our curiosity to study them to better understand their basic and clinical pharmacology

[PubMed] [Google Scholar] 217.Guatteo E., Carunchio I., Pieri M., Albo F., Canu N., Mercuri N.B., Zona C

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Arnold FH Exploring Protein Fitness Landscapes by Directed Evolution