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Future efforts should prioritize large-scale trials validating efficacy for both motor and non-motor symptoms, alongside development of personalized closed-loop systems to enhance precision

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1 A possible association between hookworm or whipworm infection and liver cancer has been reported, and cats with chronic cholangitis may have an increased predisposition to biliary carcinoma.7, 13 Several liver mitogens and tumor suppressor genes such as epidermal growth factor, TGF-, vascular endothelial growth factor (VEGF), p53, and TGF- and its receptors (TGF--r) have been associated with liver cancers in humans and these may play a similar role in the dog.14, 15, 16, 17 In human medicine a small percentage of HCCs or cholangiocarcinomas originate from hepatic progenitor stem cells

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