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Another serious complication associated with the use of KD involves potential changes in the lipid profile, particularly an increase in low-density lipoprotein (LDL) cholesterol (48)

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IDD is a leading cause of chronic lower back pain with pathological mechanisms involving nucleus pulposus cell (NPC) apoptosis, extracellular matrix (ECM) degradation, an imbalanced inflammatory microenvironment and oxidative stress damage (12,13)
