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However, as common obesity is a state of leptin resistance, the exogenous administration of even exceedingly high doses of leptin has proven relatively ineffective at reducing body weight [14-16]
10.5863/1551-6776-19.1.60 [DOI] [PMC free article] [PubMed] 17.Page MJ, McKenzie JE, Bossuyt PM et al (2020) statement: an updated guideline for reporting systematic reviews

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