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This condition is experienced by 15% of those with male-factor infertility and 1% of the general male population

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Research indicates that the sustained high expression of EN2 during prenatal and early postnatal periods contributes to autism by affecting the maturation of cerebellar purkinje cells ( in vitro studies reveals that En2 increases the complexity of GABAergic neuron dendritic trees, reduces the number of mature synapses, and decreases the area of postsynaptic density ( 3.2.3.7 DLX and MET In addition, genes related to GABA function play a significant role in the pathogenesis of ASD