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1.6.7 Analysis of COS Release from 7a-d in the Presence of N-Acetyl-Cysteine Using MIMS COS was analyzed using a Hiden HPR-40 MIMS system with a sample cell and membrane probe that have been optimized to detect gases dissolved in aqueous solution as described previously

This SCFA-mediated reinforcement of intercellular junctions reduces the risk of increased intestinal permeability, commonly referred to as leaky gut, a pathological condition that enables the translocation of luminal antigens and other deleterious molecules into the systemic circulation (170)

Key Research Focus Areas Gastrointestinal Physiology Evaluation of cagrilintides effects on intestinal motility, absorption, and mucosal integrity through its GLP-2 receptor-mediated pathways