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Duan B, Hockaday LA, Kang KH, et al

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This phenotype highlights the vicious cycle of ROS-induced mitochondrial damage perpetuating further ROS release

The upregulation of NMN suggests that it may activate Sirtuin-mediated autophagy, thereby accelerating the turnover of proteins damaged by oxidative stress

doi: 10.1126/science.1164680 104 DixonSJLembergKMLamprechtMRSkoutaRZaitsevEMGleasonCEet al
