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Science 345:1250256

W.JinS.LeeJ

However, in clinical practice, it is important to carefully evaluate and individually manage patients who require PPI therapy to avoid long-term abuse

doi: 10.1161/CIRCULATIONAHA.116.021881 163 YanN.XuZ.QuC.ZhangJ

Sterol regulatory element-binding proteins (SREBPs), peroxisome proliferator-activated receptor-alpha (PPAR-), AMP-activated protein kinase (AMPK), mitogen-activated protein kinase (MAPK), nuclear factor erythroid 2-related factor 2 (Nrf2), sirtuins1 (SIRT1), and nuclear factor kappa B (NF-B), fatty acid synthase (FAS), glutathione (GSH), oxidized glutathione (GSSG), 4-hydroxynonenal (4-HNE) and malondialdehyde-acetaldehyde adducts (MAA)