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Moreover, non-protein-bound iron may also increase the activity of iron-containing enzymes such as prolyl hydroxylase (PHD)Dependent proteasomal system 23 , which plays a key role in the degradation of hypoxia-inducible factor-1 alpha (HIF-1) 24

In conclusion, numerous studies underscore the clinical importance of the ketogenic diet and ketone bodies in the management and diagnosis of pancreatic cancer patients

Groeger D, OMahony L, Murphy EF, et al

Cytochrome b5 reductase (CBR) deficiency is an enzymopathy that does not cause hemolytic anemia: it instead causes recessive congenital methemoglobinemia, 29 often presenting as cyanosis in infants, that may mislead one to suspect congenital heart disease