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The base deprotonates the hydroxyl group of serine to generate the nucleophile, whereas the acid stabilizes the base by restricting the side chain rotation of the base (Matthews et al, 1967)

Zhu H, Naujokas MA, Park M

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Injecting under the skin bypasses the gut entirely, which is why the GLP-1 weight-loss drugs (semaglutide, tirzepatide) are weekly subcutaneous injections rather than ordinary pills

Survodutide, as a dual GLP-1/glucagon receptor agonist, further supports the plausibility of glucagon receptor activation as a useful therapeutic component when paired with GLP-1 signaling