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The researchers identified treatments that could be studied in clinical trials for the condition based on their potential to lower levels of the chemical compoundcalled nicotinamide adenine dinucleotide (NAD+), a form of vitamin B3
& Zierold, K
Atherosclerosis 2011;219:8759
But animal studies extending up to 6 months show no organ toxicity or adverse histological changes (Sikiric et al., Toxicology and Applied Pharmacology, 2019)
If a significant deficiency is left untreated over time, some of this nerve damage can become permanent, which is why prompt evaluation matters
