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doi: 10.1053/j.gastro.2008.10.055

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The proposed mechanism involves potentiation of existing opioid tone rather than direct opioid receptor agonism, which may explain the absence of classical tolerance and dependence patterns

A peptide derived from the p53 activation domain binds to a specific site on the surface of the TAZ2 domain [149] This indicates the ability of the peptides to regulate the activity of CBP and p300 proteins by binding to the TAZ zinc finger domain

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