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Surviving cells that were previously hypoxic may begin to proliferate following loss of killed cells closer to blood vessels, leading to improvement in the distribution of oxygen and nutrient metabolites, and therefore may allow regrowth of the tumor (see Sec

Antibodies contain a paratope, a small region at the antibody's tip that binds to the antigen epitope with high affinity

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Additionally, in RNAi processes, the 5 nucleobase affects the binding activity of AGOs to siRNA, thus reducing target cleavage activity