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81 , e0004016 (2017)

4f, g), a hallmark of activated PSC, which was in concordance with the observed NF-B activation (Fig

The project revealed a novel mechanism by which RanBPM regulates p21 protein stability, and plays a critical role in the regulation of DDR, thereby suggesting that it might be a promising therapeutic strategy to develop small molecular compounds destroying the protein interaction between RanBPM and p21

Protein malabsorption can lead to severe weight loss, muscle wasting, and hypoalbuminemia, manifesting clinically as peripheral edema

Anti- and pro-oxidant mechanisms of vitamin C are summarized in Figure 2