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Manifestations of glutathione synthetase deficiency usually include hemolytic anemia, often include metabolic acidosis, and sometimes include progressive neurologic symptoms as well as other systemic signs

Even though experimental and observational studies show a significant correlation between elevated levels of plasma TMAO and adverse cardiovascular events, the precise mechanism is still in place and unidentified [11]

In its main 56-week clinical trial, patients on the highest dose lost an average of 8 percent of their starting body weight

doi: 10.1016/S1071-55760300116-3 33 MallardBDekkersJIrelandMLeslieKSharifSVankampenCLet al

Autophagy: Biology and Diseases
