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Daraee H, Etemadi A, Kouhi M, et al

There is growing consensus regarding their pathophysiology and management, but more work is needed to elucidate the relationships between irAEs and treatment outcomes, specific biomarkers that clinch an irAE diagnosis, the impact of tailored immunosuppression on ICI outcomes, and the management of steroid-refractory irAEs

Variable importance of the projection (VIP) values of metabolites were obtained from these OPLS-DA models, and the fold changes (FC) and p -values of metabolites were obtained with MetaboAnalyst 5.0 based on the intensities of the spectrum

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Thus, the health-promoting effects of dietary fruits and vegetables likely reflect a complex interaction among many naturally occurring compounds, which has not been duplicated by consumption of isolated antioxidant compounds