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Interestingly, among nine aging-related metabolites that decrease among the elderly 7 , three (OA, leucine, and isoleucine) greatly increased during fasting, implying that fasting might affect also aging-related compounds

6.2 Endotoxemia Lipopolysaccharide (LPS, synonymous as endotoxin) is a major constituent of the outer cell wall of all gram-negative bacteria that can trigger the synthesis and release of pro-inflammatory cytokines and inducible nitric oxide synthase (iNOS) [153,154]