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2015 measured permeation through human skin samples held in a Franz cell apparatus, not living skin on a living person 3
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Moreover, unbound volume of distribution in the brain parenchymal cells (V u,cell ) estimated using the brain homogenate method and cerebral microdialysis can be combined with V u,brain to estimate unbound (pro)drug concentration ratio in intra- and extracellular compartments of the brain (K p,uu,cell ) (87)
10.1016/j.bbrc.2013.09.019 36 ColpittsS
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