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However, recurrent bouts of such inflammation and the toxic milieu that ensues, are thought to produce cumulative damage to myelin, oligodendrocytes and neurons, leading to progressive degeneration, atrophy and increasing disability, exacerbated by failure of myelin repair

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As such, Bv8 promotes differentiation of myeloid-derived ( suppressor) stem (remove word stem) cells (MDSCs) and induces their mobilization to the peripheral blood and infiltration into the tumor microenvironment