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Patient-derived tumor organoids (PDOs) represent an important step toward bridging preclinical and clinical research

Normally, valproate is metabolized largely in the liver into valproate glucuronide

Finally, we discuss how dysregulated ECM remodelling leads to diseases such as fibrosis and cancer and highlight some ECM-related targets with therapeutic potential that are currently being tested in clinical trials

Mutation in BRCA1 is associated with early onset and high-grade TNBC, whereas mutation in the BRCA2 gene is more often responsible for estrogen receptor-positive (ER+) subtypes

In our study, sperm motility, deformity rates and the sperm counts of rats from the high-altitude model were assessed, and a preliminary analysis of sperm morphology was performed