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Higher cortisol levels in the evening suggest the preservation of a foetal-type diurnal rhythm

For instance, doxorubicin, a topoisomerase inhibitor, induces DNA damage in cancer cells by interfering with topoisomerases and unwinding supercoiled DNA 24

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Published research does not directly evaluate this in human cancer patients

In severe cases, it should be remembered that the most common cause of vitamin B12 deficiency is autoimmune gastritis.7 In our patient, further tests and explorations revealed high titers of antibodies against parietal cells and intrinsic factor and chronic atrophic inflammation of the gastric mucosa