glutathione s transferase catalytic mechanism The role of glutathione-S-transferase in anti-cancer drug resistance Glutathione S-transferase - Wikipedia

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[DOI] [PubMed] [Google Scholar] 275.Dringen R., Bishop G.M., Koeppe M., Dang T.N., Robinson S.R

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A normal homocysteine excludes significant B vitamin deficiency.15,18 Liver disease : Elevated Hcy and low levels of SAM are associated with liver toxicity and cirrhosis.19,20 Homocysteine may cause liver damage, leading to the formation of fibrin, clots, and vascular complications.21 Renal disease : homocysteine levels rise during renal insufficiency due to inadequate homocysteine filtration.22,23 Thyroid conditions : Elevated homocysteine levels may contribute to accelerated heart disease in patients with concomitant hypothyroidism.24 Alzheimers disease and dementia : Elevated homocysteine levels have been associated with Alzheimers disease incidence, indicating impaired methylation in brain tissue.25,26,27 Depression : Low serum folic acid levels have been associated with depression in women.28,29 Of interest, low levels of serum folate reduce the efficacy of fluoxetine (Prozac, an antidepressant),28 while Vitamin B6 may alleviate depression.30 Erectile dysfunction : A case study described a patient with erectile dysfunction who had a genetic defect causing elevated serum homocysteine levels