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The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

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CanaveseCPetraruloMMassarentiPBeruttiSFenoglioRPaulettoDet alLong-term, low-dose, intravenous vitamin C leads to plasma calcium oxalate supersaturation in hemodialysis patients

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10.1016/s0378-5955(03)00065-0 30 HurtleyC.World Health Organization (2009)

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Conversely, integrase strand transfer inhibitors (INSTIs) such as Dolutegravir and Raltegravir are generally considered to have the most favorable mitochondrial safety profile, with little evidence of direct mtDNA toxicity

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