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A crucial next step in drug development, several experts told Undark, is to test for safety and efficacy in humans

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Marks (Great Ormond Street Hospital for Children, London, UK)

Inducers of CYP3A4 The concomitant use of oxycodone and acetaminophen tablets and CYP3A4 inducers, such as rifampin, carbamazepine, and phenytoin, can decrease the plasma concentration of oxycodone [see CLINICAL PHARMACOLOGY], resulting in decreased efficacy or onset of a withdrawal syndrome in patients who have developed physical dependence to oxycodone and acetaminophen tablets [see WARNINGS]

PMID: 37269775 EMBO J 2023 Jan 16;42(2):e111268