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2) Due to the extremely complex signaling pathways in the regulation of normal cellular biology, inhibition of a specific signaling pathway will definitely have feedback activation or upregulation of other alternative signaling pathways, therefore causing ultimately treatment failure

[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Matsumoto M., Shannon Weickert C., Akil M., Lipska B.K., Hyde T.M., Herman M.M., Kleinman J.E., Weinberger D.R

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