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Description
As a result, DES(1-3) IGF-1 exhibits roughly 10-fold greater potency than native IGF-1 in cell-based assays, despite identical IGF1R binding affinity the potency difference is entirely attributable to less sequestration

Wang W, Green M, Choi JE, et al
Like the mythological Chimera, this new protein displays three different characteristics: it has the head of all SODs, namely the ability to remove superoxide

doi: 10.1016/j.ijbiomac.2019.10.263 70
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