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SUPEROXIDE, HYDROGEN PEROXIDE, AND PEROXYNITRITE GENERATION Despite the fact that superoxide can be generated in extramitochondrial reactions, in most cell types mitochondria appear as the main source of superoxide generation

1A and EV1A,B, Methods)

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PKM2 also controls flux into the serine biosynthesis pathway [42], which supports glutathione production [43, 44]
