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Indeed, proteins, lipids, nucleic acids, enzymes, cellular division, and cellular metabolism are highly affected, being associated with the development and progression of several diseases, such as cancer [5,8,10]

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Recent developments in automated sampling of blood (159) and tissue interstitial fluid via microdialysis (160) have also uncovered the ultradian rhythms in plasma ACTH which correlate well with plasma and tissue steroid (cortisol and cortisone) concentrations, indicating that the ultradian rhythms in blood ACTH and cortisol/cortisone translate well to tissue exposure to these steroids

Heat-shock proteins (HSPs) activated during sauna sessions stabilize cellular proteins, repair cellular damage, and influence BDNF synthesis and release