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7 Although supplements lack the same quality and safety data required of pharmaceuticals, adverse reactions to supplements make up only 1.3% of adverse drug event visits to the emergency department, compared to 21.4% for pharmaceutical drugs

The strength of correlation between maximum CMAP amplitude and our primary outcome measure, the MHFMS, suggests that in non-ambulatory patients with SMA the CMAP may be a robust surrogate outcome measure for assessing treatment interventions if the putative mechanism of effect is to enhance innervated muscle mass by reinnervation or other trophic effects on nerve or muscle

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