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Excessive accumulation of ROS induces oxidative stress, which can cause damage to biological macromolecules such as carbohydrates, lipids, nucleic acids, and proteins, impairing the regular functional integrity of cells in the body 12
Indicates that no adverse fetal effects have been observed at normal doses and that pyridoxine is considered safe and often beneficial in pregnancy
It can also promote chemoresistance of non-small cell lung cancer brain metastases by targeting GPX4 and binding to the GPX4 promoter region [90]
Cysteine dioxygenase
