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First, homocysteine (Hcy) is quite a bit lower in females than in males

the other is heme oxygenase-1 (HO-1), it promotes the breakdown of heme into ferric ions and is controlled with the nuclear factor erythrocyte 2-related factor 2 (NRF2) gene, leading to ex vivo and in vivo mitochondrial iron overload (Chang et al., 2023)

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We summarize mechanistic insights across cellular and molecular domains, critically appraise preclinical and clinical findings, and discuss translational challenges that include bioavailability and brain penetration, study heterogeneity, biomarker guided stratification, and pediatric safety

BPC-157 is unique in that it can potentially allow the body to self-heal