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The MHRA advises checking B12 levels in patients taking metformin who develop symptoms of deficiency or have risk factors, with periodic monitoring in at-risk patients

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This classification means that such injections can only be prescribed by a qualified healthcare professional and are not available for over-the-counter purchase

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All effect size measures such as odds ratio (OR) and 95% confidence intervals (95%CI), hazard ratio (HR), relative risk (RR and 95%CI), mean (standard deviation, SD), and median (and any measure of data dispersion), were eligible